2714473-70-6
Chemical Structure
Lamivudine-13C,d2
- CAS No.: 2714473-70-6
- Formula:C713CH9D2N3O3S
- Molecular Weight:232.26
IUPAC Name: 4-amino-1-((2R,5S)-2-(hydroxymethyl-d2)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one-2-13C
InChIKey: JTEGQNOMFQHVDC-PPUZHDCLSA-N
SMILES: NC1=N[13C](N([C@@H]2CS[C@H](C(O)([2H])[2H])O2)C=C1)=O
Biological Activity: Lamivudine-13C,d2 is the deuterium labeled and 13C-labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS[1][2].
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Lamivudine-13C,d2 | Lamivudine-13C,d2 is the deuterium labeled and 13C-labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS. | |||||||||||||||||||||
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- [1]. Colledge D, et al. Synergistic inhibition of hepadnaviral replication by lamivudine in combination with penciclovir in vitro. Hepatology. 1997 Jul;26(1):216-25. [Content Brief]
- [2]. Olaniyan LW, et al. Lamivudine-Induced Liver Injury. Open Access Maced J Med Sci. 2015 Dec 15;3(4):545-50. [Content Brief]
Keywords
