2732914-43-9
Chemical Structure
Angustilongine M
- CAS No.: 2732914-43-9
- Formula:C41H48N4O3
- Molecular Weight:644.84
SMILES: C[C@H]1C2=C(O[C@@]3([H])[C@]1([H])[C@@]4([H])[C@@]([C@]5([H])CC6=C(N(C7=CC=CC=C76)C)[C@](N5C)([H])C4)([H])CO3)C=CC8=C2C9=C([C@@]%10([H])[N@@]%11[C@@]([C@@H]([C@](/C(C%11)=C\C)([H])C%10)CO)([H])C9)N8C
Biological Activity: Angustilongine M is a microtubule-targeting antitumor alkaloid (IC50=0.2 μM against HT-29 cells). Angustilongine M induces G0/G1 cell cycle arrest and mitochondrial apoptosis via tubulin polymerization promotion. Angustilongine M is promising for research of colorectal cancer and other solid tumors[1].
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Angustilongine M | Angustilongine M is a microtubule-targeting antitumor alkaloid (IC50=0.2 μM against HT-29 cells). Angustilongine M induces G0/G1 cell cycle arrest and mitochondrial apoptosis via tubulin polymerization promotion. Angustilongine M is promising for research of colorectal cancer and other solid tumors. | |||||||||||||||||||||
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Keywords
