2738376-73-1
Chemical Structure
Vapendavir-d5
Synonym(s): BTA798-d5
- CAS No.: 2738376-73-1
- Formula:C21H21D5N4O3
- Molecular Weight:387.49
IUPAC Name: 3-(ethoxy-d5)-6-(2-(1-(6-methylpyridazin-3-yl)piperidin-4-yl)ethoxy)benzo[d]isoxazole
InChIKey: DKSVBVKHUICELN-WNWXXORZSA-N
SMILES: [2H]C([2H])([2H])C([2H])([2H])OC1=NOC2=CC(OCCC3CCN(C4=CC=C(N=N4)C)CC3)=CC=C12
Biological Activity: Vapendavir-d5 is the deuterium labeled Vapendavir. Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains[1][2].
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Vapendavir-d5 | Vapendavir-d5 is the deuterium labeled Vapendavir. Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains. | |||||||||||||||||||||
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Vapendavir-d6 | Vapendavir-d6 (BTA798-d6) is deuterium-labeled Vapendavir (HY-106254). | |||||||||||||||||||||
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Vapendavir | 99.93% | Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Tijsma A, et al. The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication. Antimicrob Agents Chemother. 2014 Nov;58(11):6990-2. [Content Brief]
Keywords
