2738376-80-0
2738376-80-0
Chemical Structure
Prostaglandin J2-d4
- CAS No.: 2738376-80-0
- Formula:C20H26D4O4
- Molecular Weight:338.47
IUPAC Name: (Z)-7-((1S,5R)-5-((S,E)-3-hydroxyoct-1-en-1-yl)-4-oxocyclopent-2-en-1-yl)hept-5-enoic-3,3,4,4-d4 acid
InChIKey: UQOQENZZLBSFKO-KREVBJNISA-N
SMILES: CCCCC[C@@H](/C=C/[C@@H]1[C@H](C=CC1=O)C/C=C\C([2H])(C([2H])(CC(O)=O)[2H])[2H])O
Biological Activity: Prostaglandin J2-d4 is the deuterium labeled Prostaglandin J2[1].
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Prostaglandin J2-d4 | Prostaglandin J2-d4 is the deuterium labeled Prostaglandin J2. | |||||||||||||||||||||
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Prostaglandin J2 | 98.1% | Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD). | ||||||||||||||||||||
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References
Keywords
