2745118-93-6
2745118-93-6
Chemical Structure
BuChE-IN-2
- CAS No.: 2745118-93-6
- Formula:C28H20F4N6O3
- Molecular Weight:564.49
IUPAC Name: 2-(2-isopropylphenyl)acetonitrile
InChIKey: QVBGPENLPOKABU-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C2=NC(C3=CC(NC4=CC=C(OC(F)(F)F)C=C4)=NC=C3)=NO2)C=C1)CNC5=CC=C(F)C=C5
Biological Activity: BuChE-IN-2 is an excellent butyrylcholinesterase (BuChE) inhibitor (IC50s of 1.28 μM and 0.67 μM for BuChE and NO). BuChE-IN-2 can inhibit the aggregation of Aβ, ROS formation and chelate Cu2+, exhibiting proper blood-brain barrier (BBB) penetration. BuChE-IN-2 has potential to research Alzheimer’s disease[1].
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BuChE-IN-2 | BuChE-IN-2 is an excellent butyrylcholinesterase (BuChE) inhibitor (IC50s of 1.28 μM and 0.67 μM for BuChE and NO). BuChE-IN-2 can inhibit the aggregation of Aβ, ROS formation and chelate Cu2+, exhibiting proper blood-brain barrier (BBB) penetration. BuChE-IN-2 has potential to research Alzheimer’s disease. | |||||||||||||||||||||
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References
Keywords
