2752755-32-9
Chemical Structure
β-Naphthoflavone-CH2-OH
Synonym(s): β-NF-CH2-OH
- CAS No.: 2752755-32-9
- Formula:C20H14O3
- Molecular Weight:302.32
IUPAC Name: 3-(4-(hydroxymethyl)phenyl)-1H-benzo[f]chromen-1-one
InChIKey: DNYHKVXLVTVFPG-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(CO)C=C2)OC3=C1C4=CC=CC=C4C=C3
Biological Activity: β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) is a ligand for arylhydrocarbon receptor (AhR) E3 ligase. β-Naphthoflavone-CH2-OH can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1) that recruit the AhR E3 ligase complex by incorporating AhR ligands into chimeric molecules. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins [1].
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β-Naphthoflavone-CH2-OH | β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) is a ligand for arylhydrocarbon receptor (AhR) E3 ligase. β-Naphthoflavone-CH2-OH can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1) that recruit the AhR E3 ligase complex by incorporating AhR ligands into chimeric molecules. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins . | |||||||||||||||||||||
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Keywords
