2. PROTAC
  3. Ligands for E3 Ligase
  4. β-Naphthoflavone-CH2-OH

β-Naphthoflavone-CH2-OH  (Synonyms: β-NF-CH2-OH)

Cat. No.: HY-130269
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β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) is a ligand for arylhydrocarbon receptor (AhR) E3 ligase. β-Naphthoflavone-CH2-OH can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1) that recruit the AhR E3 ligase complex by incorporating AhR ligands into chimeric molecules. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

For research use only. We do not sell to patients.

β-Naphthoflavone-CH2-OH Chemical Structure

β-Naphthoflavone-CH2-OH Chemical Structure

CAS No. : 2752755-32-9

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β-Naphthoflavone-CH2-OH Related Antibodies

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Description

β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) is a ligand for arylhydrocarbon receptor (AhR) E3 ligase. β-Naphthoflavone-CH2-OH can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1) that recruit the AhR E3 ligase complex by incorporating AhR ligands into chimeric molecules. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins [1].

IC50 & Target[1]

cIAP1

 

Molecular Weight

302.32

Formula

C20H14O3
CAS No.
SMILES

O=C1C=C(C2=CC=C(CO)C=C2)OC3=C1C4=CC=CC=C4C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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β-Naphthoflavone-CH2-OH Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Naphthoflavone-CH2-OH2752755-32-9β-NF-CH2-OHLigands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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