2758117-74-5
Chemical Structure
PARP1/BRD4-IN-1
- CAS No.: 2758117-74-5
- Formula:C29H26N6O3
- Molecular Weight:506.56
IUPAC Name: 2-((6-(3,5-dimethylisoxazol-4-yl)-1-methyl-2-oxo-4-phenyl-1,4-dihydroquinazolin-3(2H)-yl)methyl)-1H-benzo[d]imidazole-7-carboxamide
InChIKey: JHEWPSFLMCUPRO-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC2=C1NC(CN3C(N(C)C4=CC=C(C5=C(C)ON=C5C)C=C4C3C6=CC=CC=C6)=O)=N2)N
Biological Activity: PARP1/BRD4-IN-1 is a potent and high selective PARP1/BRD4 inhibitor (IC50s of 49 and 202 nM in PARP1 and BRD4, respectively). PARP1/BRD4-IN-1 represses the expression and activity of PARP1 and BRD4 to synergistically inhibit the malignant growth of pancreatic cancer cells[1].
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PARP1/BRD4-IN-1 | PARP1/BRD4-IN-1 is a potent and high selective PARP1/BRD4 inhibitor (IC50s of 49 and 202 nM in PARP1 and BRD4, respectively). PARP1/BRD4-IN-1 represses the expression and activity of PARP1 and BRD4 to synergistically inhibit the malignant growth of pancreatic cancer cells. | |||||||||||||||||||||
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Keywords
