2761538-66-1
Chemical Structure
AL-GDa62
- CAS No.: 2761538-66-1
- Formula:C24H28FN3O
- Molecular Weight:393.50
IUPAC Name: N-(4-fluorobenzyl)-2-methyl-6-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine
InChIKey: BULOKVUWCOMRHU-UHFFFAOYSA-N
SMILES: FC(C=C1)=CC=C1CNC2=CC(C)=NC3=C2C=C(OCCCN4CCCC4)C=C3
Biological Activity: AL-GDa62 is a derivative of the CDH1/E-cadherin modulator SLEC-11 (HY-145268) and induces apoptosis in CDH1-/- cells. AL-GDa62 has an EC50 of 3.2 μM and 2 μM for isogenic mammary epithelial cells MCF10A-WT (wild type) and mutant MCF10A-CDH1-/-, respectively. AL-GDa62 specifically inhibits TCOF1, ARPC5, and UBC9, and suppresses SUMOylation at low micromolar concentrations[1].
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AL-GDa62 | AL-GDa62 is a derivative of the CDH1/E-cadherin modulator SLEC-11 (HY-145268) and induces apoptosis in CDH1-/- cells. AL-GDa62 has an EC50 of 3.2 μM and 2 μM for isogenic mammary epithelial cells MCF10A-WT (wild type) and mutant MCF10A-CDH1-/-, respectively. AL-GDa62 specifically inhibits TCOF1, ARPC5, and UBC9, and suppresses SUMOylation at low micromolar concentrations. | |||||||||||||||||||||
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Keywords
