SLEC-11
SLEC-11 is a CDH1/E-cadherin modulator that potently inhibits cell death in E-cadherin-deficient cells (EC50=8.2 μM). SLEC-11 can be used to study potential synthetic lethal therapies for gastric cancer.
For research use only. We do not sell to patients.
- CAS No.: 863761-17-5
- Formula: C18H17FN2O
- Molecular Weight:296.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF-10A | EC50 |
12.2 μM
Compound: 1;SLEC-11
|
Antitumor activity against human spontaneously immortalized wild type MCF-10A cells assessed as cell numbers measured after 48 hrs
Antitumor activity against human spontaneously immortalized wild type MCF-10A cells assessed as cell numbers measured after 48 hrs
|
[PMID: 34878770] |
| MCF-10A | EC50 |
8.2 μM
Compound: 1;SLEC-11
|
Antitumor activity against human spontaneously immortalized CDH-/- MCF10A cells assessed as cell numbers measured after 48 hrs
Antitumor activity against human spontaneously immortalized CDH-/- MCF10A cells assessed as cell numbers measured after 48 hrs
|
[PMID: 34878770] |
Chemical Information
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CAS No. 863761-17-5
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Molecular Weight 296.34
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Formula C18H17FN2O
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SMILES
FC1=CC=C(CNC2=CC(C)=NC3=C2C=C(OC)C=C3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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