2762296-44-4
Chemical Structure
FLT3/CDK4-IN-1
- CAS No.: 2762296-44-4
- Formula:C25H28F2N8
- Molecular Weight:478.54
IUPAC Name: N-(4-(4-ethylpiperazin-1-yl)-3-fluorophenyl)-5-fluoro-4-(1-isopropyl-1H-pyrazolo[4,3-b]pyridin-6-yl)pyrimidin-2-amine
InChIKey: LGEMUEDLVOKLKH-UHFFFAOYSA-N
SMILES: CC(N1N=CC2=NC=C(C3=NC(NC4=CC=C(N5CCN(CC)CC5)C(F)=C4)=NC=C3F)C=C21)C
Biological Activity: FLT3/CDK4-IN-1 is a potent, high selective and orally active FLT3/CDK4 dual inhibitor (IC50=11 and 7 nM for FLT3 and CDK4, respectively). FLT3/CDK4-IN-1 has antiproliferative activities against certain cancer cells. FLT3/CDK4-IN-1 has good antitumor effect in vivo[1].
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FLT3/CDK4-IN-1 | FLT3/CDK4-IN-1 is a potent, high selective and orally active FLT3/CDK4 dual inhibitor (IC50=11 and 7 nM for FLT3 and CDK4, respectively). FLT3/CDK4-IN-1 has antiproliferative activities against certain cancer cells. FLT3/CDK4-IN-1 has good antitumor effect in vivo. | |||||||||||||||||||||
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Keywords
