2764662-16-8
2764662-16-8
Chemical Structure
RORγt/DHODH-IN-3
- CAS No.: 2764662-16-8
- Formula:C24H26ClF6N3O3S
- Molecular Weight:585.99
IUPAC Name: (S)-1-(4-(5-chloro-3-((4-hydroxy-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)amino)-2-methylphenoxy)piperidin-1-yl)-4,4,4-trifluoro-3-(trifluoromethyl)butan-1-one
InChIKey: AFZMZLHHVUIZBS-INIZCTEOSA-N
SMILES: CC1=C(C=C(C=C1NC2=NC3=C(S2)CCC[C@@H]3O)Cl)OC4CCN(CC4)C(CC(C(F)(F)F)C(F)(F)F)=O
Biological Activity: RORγt/DHODH-IN-3 (compound (S)-14d) is a dual RORγt/DHODH inhibitor, with IC50s of 0.098 μM and 0.432 μM, respectively. RORγt/DHODH-IN-3 exhibits remarkable in vivo anti-inflammatory activity[1].
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RORγt/DHODH-IN-3 | RORγt/DHODH-IN-3 (compound (S)-14d) is a dual RORγt/DHODH inhibitor, with IC50s of 0.098 μM and 0.432 μM, respectively. RORγt/DHODH-IN-3 exhibits remarkable in vivo anti-inflammatory activity. | |||||||||||||||||||||
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References
Keywords
