1. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  2. ROR Dihydroorotate Dehydrogenase
  3. RORγt/DHODH-IN-3

RORγt/DHODH-IN-3 (compound (S)-14d) is a dual RORγt/DHODH inhibitor, with IC50s of 0.098 μM and 0.432 μM, respectively. RORγt/DHODH-IN-3 exhibits remarkable in vivo anti-inflammatory activity.

For research use only. We do not sell to patients.

RORγt/DHODH-IN-3 Chemical Structure

RORγt/DHODH-IN-3 Chemical Structure

CAS No. : 2764662-16-8

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Description

RORγt/DHODH-IN-3 (compound (S)-14d) is a dual RORγt/DHODH inhibitor, with IC50s of 0.098 μM and 0.432 μM, respectively. RORγt/DHODH-IN-3 exhibits remarkable in vivo anti-inflammatory activity[1].

Molecular Weight

585.99

Formula

C24H26ClF6N3O3S

CAS No.
SMILES

CC1=C(C=C(C=C1NC2=NC3=C(S2)CCC[C@@H]3O)Cl)OC4CCN(CC4)C(CC(C(F)(F)F)C(F)(F)F)=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
RORγt/DHODH-IN-3
Cat. No.:
HY-142847
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