2766575-48-6
2766575-48-6
Chemical Structure
SWTX-143
- CAS. Nr.: 2766575-48-6
- Formula:C19H18F3N3O
- Molecular Weight:361.36
InChIKey: YZNSUDZUJLMKNI-UHFFFAOYSA-N
SMILES: O=C(C=C)NC1CC2=C(N)C=CC=C2N(C3=CC=C(C(F)(F)F)C=C3)C1
Biological Activity: SWTX-143 is an orally active YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity[1].
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SWTX-143 | 99.29% | SWTX-143 is an orally active YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity. | ||||||||||||||||||||
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References
Keywords
