2840558-83-8
2840558-83-8
Chemical Structure
Aurora kinase-IN-3
- CAS No.: 2840558-83-8
- Formula:C20H16F3N3O4
- Molecular Weight:419.35
IUPAC Name: 3-((2'-methoxy-[3,4'-bipyridin]-2-yl)oxy)-N-methyl-5-(trifluoromethoxy)benzamide
InChIKey: NVMJCTQSUKIXBG-UHFFFAOYSA-N
SMILES: CNC(C1=CC(OC(F)(F)F)=CC(OC2=C(C=CC=N2)C3=CC(OC)=NC=C3)=C1)=O
Biological Activity: Aurora kinase-IN-3 (Compound 15a) is an orally active AURKB inhibitor that elicits an AURKB-suppressive activity by disrupting the mitotic localization of AURKB, rather than inhibiting its phosphorylation of H3 at Ser10[1].
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Aurora kinase-IN-3 | 99.02% | Aurora kinase-IN-3 (Compound 15a) is an orally active AURKB inhibitor that elicits an AURKB-suppressive activity by disrupting the mitotic localization of AURKB, rather than inhibiting its phosphorylation of H3 at Ser10. | ||||||||||||||||||||
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References
Keywords
