2857845-34-0
Chemical Structure
TGFβ-IN-3
- CAS No.: 2857845-34-0
- Formula:C79H114ClFN16O20
- Molecular Weight:1662.30
IUPAC Name: (5S,11S,14S,37S)-1-amino-37-carboxy-5-((4-(((((2-(4-(3-chloro-4-fluorophenyl)-5-(3-cyanoimidazo[1,2-b]pyridazin-6-yl)-1H-imidazol-1-yl)ethoxy)methyl)carbamoyl)oxy)methyl)phenyl)carbamoyl)-11-(hydroxymethyl)-14-isobutyl-7,10,13,16,25,34,39-heptaoxo-18,21,27,30-tetraoxa-6,9,12,15,24,33,38-heptaazahexapentacontan-56-oic acid
InChIKey: IAPPCBWDGUDDEU-YKIMTJKASA-N
SMILES: OC(CCCCCCCCCCCCCCCCC(N[C@H](C(O)=O)CCC(NCCOCCOCC(NCCOCCOCC(N[C@@H](CC(C)C)C(N[C@@H](CO)C(NCC(N[C@@H](CCCCN)C(NC(C=C1)=CC=C1COC(NCOCCN2C(C3=NN4C(C=C3)=NC=C4C#N)=C(C5=CC(Cl)=C(C=C5)F)N=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: TGFβ-IN-3 (Compound 8) is a long-acting tumor-activating prodrug of TGFβR1 inhibitor. TGFβ-IN-3 can achieve selective drug release in tumors, and the tumor/blood ratio is increased by 2.2 times. TGFβ-IN-3 can be used for the study of colon cancer[1].
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TGFβ-IN-3 | TGFβ-IN-3 (Compound 8) is a long-acting tumor-activating prodrug of TGFβR1 inhibitor. TGFβ-IN-3 can achieve selective drug release in tumors, and the tumor/blood ratio is increased by 2.2 times. TGFβ-IN-3 can be used for the study of colon cancer. | |||||||||||||||||||||
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Keywords
