2891574-93-7
2891574-93-7
Chemical Structure
EF-4-177
- CAS No.: 2891574-93-7
- Formula:C18H14F5N3O2S
- Molecular Weight:431.38
InChIKey: DODVGTHDEMMYPW-UHFFFAOYSA-N
SMILES: N#CC1=CC2=C(C(CCNC3=C(C=C(C=C3)S(F)(F)(F)(F)F)C(O)=O)=CN2)C=C1
Biological Activity: EF-4-177 is an orally active and allosteric CDK2 inhibitor with the IC50 of 87 nM. EF-4-177 can disrupt spermatogenesis[1][2].
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EF-4-177 | EF-4-177 is an orally active and allosteric CDK2 inhibitor with the IC50 of 87 nM. EF-4-177 can disrupt spermatogenesis. | |||||||||||||||||||||
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References
- [1]. Faber EB, et al. Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J Med Chem. 2023;66(3):1928-1940. [Content Brief]
- [2]. Huang Y, et al. Targeting cyclin-dependent kinases: From pocket specificity to drug selectivity. Eur J Med Chem. Published online May 29, 2024. [Content Brief]
Keywords
