2923800-62-6
Chemical Structure
ATR-IN-23
- CAS No.: 2923800-62-6
- Formula:C20H22N6O3S2
- Molecular Weight:458.56
IUPAC Name: (R)-N-methyl-1-(4-(3-methylmorpholino)-7-(methylsulfonyl)thieno[3,2-d]pyrimidin-2-yl)-1H-benzo[d]imidazol-2-amine
InChIKey: ILKWBAFOIJQVMU-GFCCVEGCSA-N
SMILES: CNC1=NC2=C(N1C3=NC4=C(C(N5CCOC[C@H]5C)=N3)SC=C4S(C)(=O)=O)C=CC=C2
Biological Activity: ATR-IN-23 (Compound 34) is a potent and selective ATR inhibitor with an IC50 of 1.5 nM. ATR-IN-23 has potent antiproliferative effects on LoVo cells and synthetic lethality on HT-29 cells, and can be used in the study of DNA damage response (DDR)-deficient cancers[1].
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ATR-IN-23 | ATR-IN-23 (Compound 34) is a potent and selective ATR inhibitor with an IC50 of 1.5 nM. ATR-IN-23 has potent antiproliferative effects on LoVo cells and synthetic lethality on HT-29 cells, and can be used in the study of DNA damage response (DDR)-deficient cancers. | |||||||||||||||||||||
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Keywords
