ATR-IN-23
ATR-IN-23 (Compound 34) is a potent and selective ATR inhibitor with an IC50 of 1.5 nM. ATR-IN-23 has potent antiproliferative effects on LoVo cells and synthetic lethality on HT-29 cells, and can be used in the study of DNA damage response (DDR)-deficient cancers.
For research use only. We do not sell to patients.
- CAS No.: 2923800-62-6
- Formula: C20H22N6O3S2
- Molecular Weight:458.56
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
0.003 μM
Compound: 34
|
Antiproliferative activity against human HT-29 cells in presence of AZD1390 incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HT-29 cells in presence of AZD1390 incubated for 72 hrs by CCK-8 assay
|
[PMID: 37130473] |
| HT-29 | IC50 |
0.161 μM
Compound: 34
|
Antiproliferative activity against human HT-29 cells incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HT-29 cells incubated for 72 hrs by CCK-8 assay
|
[PMID: 37130473] |
| LoVo | IC50 |
0.073 μM
Compound: 34
|
Antiproliferative activity against human LoVo cells incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human LoVo cells incubated for 72 hrs by CCK-8 assay
|
[PMID: 37130473] |
ATR-IN-23 possesses significant inhibitory potency against ATR, with an IC50 value of 1.5 nM, and displays strong antiproliferative activities against LoVo cells, with an IC50 value of 0.073 μM[1].
ATR-IN-23 exhibits moderate antiproliferative potency against HT-29 cells with an IC50 value of 0.161 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ATR-IN-23 (50 mg/kg; once a day or twice a day; p.o.; 21 days) exhibits moderate antitumor efficacy in BALB/c nude mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c nude mice[1]
-
Dosage:50 mg/kg
-
Administration:p.o., once a day or twice a day for 21 consecutive days, dissolved in a solution of DMSO (10%), solutol (10%), and saline (80%)
-
Result:Exhibited moderate antitumor efficacy, with a tumor growth inhibition (TGI) value of 55% at dosages of 50 mg/kg twice a day.
Chemical Information
-
CAS No. 2923800-62-6
-
Molecular Weight 458.56
-
Formula C20H22N6O3S2
-
SMILES
CNC1=NC2=C(N1C3=NC4=C(C(N5CCOC[C@H]5C)=N3)SC=C4S(C)(=O)=O)C=CC=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz