2951015-31-7
2951015-31-7
Chemical Structure
YDR1
- CAS. Nr.: 2951015-31-7
- Formula:C44H49FN10O5
- Molecular Weight:816.92
InChIKey: NKECFXWADFBMPA-UHFFFAOYSA-N
SMILES: O=C(N(C1CCC(NC1=O)=O)C2=O)C3=C2C=CC(N4CCN(CC5CCN(C6=C(F)C=C(CN7CCN(C8=C(N)N=NC(C9=C(O)C=CC=C9)=C8)CC7)C=C6)CC5)CC4)=C3
Biological Activity: YDR1 is an orally active and selective SMARCA2 PROTAC degrader. YDR1 selectively inhibits the growth of various cancer cells and suppresses tumor growth in mouse xenograft models. YDR1 can be used for the research of SMARCA4-mutant lung cancer[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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YDR1 | 98.06% | YDR1 is an orally active and selective SMARCA2 PROTAC degrader. YDR1 selectively inhibits the growth of various cancer cells and suppresses tumor growth in mouse xenograft models. YDR1 can be used for the research of SMARCA4-mutant lung cancer. | ||||||||||||||||||||
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References
- [1]. Kotagiri S, et al. Discovery of Novel, Potent, and Orally Bioavailable SMARCA2 Proteolysis-Targeting Chimeras with Synergistic Antitumor Activity in Combination with Kirsten Rat Sarcoma Viral Oncogene Homologue G12C Inhibitors. Journal of medicinal chemistry. 2025 May 08;68(9):9202-9219. [Content Brief]
Keywords
