29553-70-6
Chemical Structure
4-CPPC
- CAS No.: 29553-70-6
- Formula:C14H9NO6
- Molecular Weight:287.22
IUPAC Name: 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid
InChIKey: NBVHLJGGHJLTGM-UHFFFAOYSA-N
SMILES: O=C(C1=NC=C(C(O)=O)C(C2=CC=CC(C(O)=O)=C2)=C1)O
Biological Activity: 4-CPPC is a selective MIF-2 inhibitor with a Ki of 33 µM. 4-CPPC inhibits the COX2/PGE2 pathway, reduces the levels of COX2 and mPGES-1, and decreases the production of PGE2. 4-CPPC attenuates the formation of early atherosclerotic lesions in hyperlipidemic mice, and lowers the levels of circulating inflammatory cytokines and chemokines. 4-CPPC inhibits MIF-2-triggered cell migration. 4-CPPC improves hindlimb motor function in rats with contusion-induced spinal cord injury. 4-CPPC can be used in studies related to atherosclerosis and spinal cord injury[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-CPPC | 98.20% | 4-CPPC is a selective MIF-2 inhibitor with a Ki of 33 µM. 4-CPPC inhibits the COX2/PGE2 pathway, reduces the levels of COX2 and mPGES-1, and decreases the production of PGE2. 4-CPPC attenuates the formation of early atherosclerotic lesions in hyperlipidemic mice, and lowers the levels of circulating inflammatory cytokines and chemokines. 4-CPPC inhibits MIF-2-triggered cell migration. 4-CPPC improves hindlimb motor function in rats with contusion-induced spinal cord injury. 4-CPPC can be used in studies related to atherosclerosis and spinal cord injury. | ||||||||||||||||||||
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References
- [1]. El Bounkari O, et al. An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis. Nature communications. 2025 Mar 07;16(1):2297. [Content Brief]
- [2]. Ji H, et al. D-dopachrome tautomerase activates COX2/PGE2 pathway of astrocytes to mediate inflammation following spinal cord injury. J Neuroinflammation. 2021 Jun 11;18(1):130.
- [3]. Pantouris G, et al. Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor. Biochemistry. 2018 Jul 03;57(26):3599-3605. [Content Brief]
