2963747-43-3
Chemical Structure
CIB-Q22
- CAS No.: 2963747-43-3
- Formula:C18H22FNO4
- Molecular Weight:335.37
InChIKey: RUUNGRHZRCVJPY-UHFFFAOYSA-N
SMILES: NC1=C(F)C(CCC2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC
Biological Activity: CIB-Q22 is a potent pyruvate carboxylase (PC) inhibitor with an IC50 of 1.74 nM. CIB-Q22 suppresses hepatocellular carcinoma (HCC) cell proliferation, migration, and invasion. CIB-Q22 induces apoptosis and ferroptosis, promotes mitochondrial oxidative stress and dysfunction, inhibits glycolysis and anaplerotic flux, and reverses epithelial-mesenchymal transition (EMT). CIB-Q22 can be used for the study of hepatocellular carcinoma[1].
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CIB-Q22 | CIB-Q22 is a potent pyruvate carboxylase (PC) inhibitor with an IC50 of 1.74 nM. CIB-Q22 suppresses hepatocellular carcinoma (HCC) cell proliferation, migration, and invasion. CIB-Q22 induces apoptosis and ferroptosis, promotes mitochondrial oxidative stress and dysfunction, inhibits glycolysis and anaplerotic flux, and reverses epithelial-mesenchymal transition (EMT). CIB-Q22 can be used for the study of hepatocellular carcinoma. | |||||||||||||||||||||
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Keywords
