2966861-50-5
2966861-50-5
Chemical Structure
PI3Kα-IN-12
- CAS No.: 2966861-50-5
- Formula:C28H36F2N10O5S3
- Molecular Weight:726.84
InChIKey: KOBDMZOFSXEFLG-UHFFFAOYSA-N
SMILES: S=C(N1CCN(C2=NC(N3C(C(F)F)=NC4=C(OC)C=CC=C34)=NC(N5CCOCC5)=N2)CC1)SCC(N6CCN(S(=O)(C)=O)CC6)=O
Biological Activity: PI3Kα-IN-12 (compound 13) is a highly selective PI3Kα inhibitor (IC50: 1.2 nM). PI3Kα-IN-12 inhibits HCT-116 and U87-MG with IC50s values of 0.83 and 1.25 μM, respectively. PI3Kα-IN-12 (40 mg/kg; IP) causes tumor regression in a U87-MG cell line xenograft mouse model[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PI3Kα-IN-12 | PI3Kα-IN-12 (compound 13) is a highly selective PI3Kα inhibitor (IC50: 1.2 nM). PI3Kα-IN-12 inhibits HCT-116 and U87-MG with IC50s values of 0.83 and 1.25 μM, respectively. PI3Kα-IN-12 (40 mg/kg; IP) causes tumor regression in a U87-MG cell line xenograft mouse model. | |||||||||||||||||||||
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References
Keywords
