2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3Kα-IN-12

PI3Kα-IN-12 (compound 13) is a highly selective PI3Kα inhibitor (IC50: 1.2 nM). PI3Kα-IN-12 inhibits HCT-116 and U87-MG with IC50s values of 0.83 and 1.25 μM, respectively. PI3Kα-IN-12 (40 mg/kg; IP) causes tumor regression in a U87-MG cell line xenograft mouse model.

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PI3Kα-IN-12 Chemical Structure

PI3Kα-IN-12 Chemical Structure

CAS No. : 2966861-50-5

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PI3Kα-IN-12 Related Antibodies

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Description

PI3Kα-IN-12 (compound 13) is a highly selective PI3Kα inhibitor (IC50: 1.2 nM). PI3Kα-IN-12 inhibits HCT-116 and U87-MG with IC50s values of 0.83 and 1.25 μM, respectively. PI3Kα-IN-12 (40 mg/kg; IP) causes tumor regression in a U87-MG cell line xenograft mouse model[1].

IC50 & Target

PI3K[1]
Molecular Weight

726.84

Formula

C28H36F2N10O5S3
CAS No.
SMILES

S=C(N1CCN(C2=NC(N3C(C(F)F)=NC4=C(OC)C=CC=C34)=NC(N5CCOCC5)=N2)CC1)SCC(N6CCN(S(=O)(C)=O)CC6)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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PI3Kα-IN-12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kα-IN-122966861-50-5PI3KPhosphoinositide 3-kinasecell divisionU87-MGHCT-116Inhibitorinhibitorinhibit

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