PI3Kα-IN-12
PI3Kα-IN-12 (compound 13) is a highly selective PI3Kα inhibitor (IC50: 1.2 nM). PI3Kα-IN-12 inhibits HCT-116 and U87-MG with IC50s values of 0.83 and 1.25 μM, respectively. PI3Kα-IN-12 (40 mg/kg; IP) causes tumor regression in a U87-MG cell line xenograft mouse model.
For research use only. We do not sell to patients.
- CAS No.: 2966861-50-5
- Formula: C28H36F2N10O5S3
- Molecular Weight:726.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PI3K[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.83 μM
Compound: 13
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 96 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 96 hrs by MTT assay
|
[PMID: 37736169] |
| U-87MG ATCC | IC50 |
1.25 μM
Compound: 13
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Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation incubated for 96 hrs by MTT assay
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation incubated for 96 hrs by MTT assay
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[PMID: 37736169] |
Chemical Information
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CAS No. 2966861-50-5
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Molecular Weight 726.84
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Formula C28H36F2N10O5S3
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SMILES
S=C(N1CCN(C2=NC(N3C(C(F)F)=NC4=C(OC)C=CC=C34)=NC(N5CCOCC5)=N2)CC1)SCC(N6CCN(S(=O)(C)=O)CC6)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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