2999645-23-5
2999645-23-5
Chemical Structure
SR-4133
- CAS No.: 2999645-23-5
- Formula:C27H22F2N8O
- Molecular Weight:512.51
InChIKey: DOPHVIBXJOSQHB-UHFFFAOYSA-N
SMILES: FC1=C(F)C2=C(NC(CNC3=NC(N4CCOCC4)=NC5=C3N=CN5C6=CC(C=CC=C7)=C7C=C6)=N2)C=C1
Biological Activity: SR-4133 is a potent and highly CK1ε selective inhibitor with an IC50 of 58 nM. SR-4133 binds to the ATP-binding site of CK1ε. SR-4133 displays nanomolar growth inhibition of bladder cancer cells, and inhibits the phosphorylation of 4E-BP1[1].
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SR-4133 | SR-4133 is a potent and highly CK1ε selective inhibitor with an IC50 of 58 nM. SR-4133 binds to the ATP-binding site of CK1ε. SR-4133 displays nanomolar growth inhibition of bladder cancer cells, and inhibits the phosphorylation of 4E-BP1. | |||||||||||||||||||||
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References
Keywords
