3008290-92-1
3008290-92-1
Chemical Structure
XJTU-L453
- CAS. Nr.: 3008290-92-1
- Formula:C22H22N4O3
- Molecular Weight:390.44
InChIKey: ZAAQWCBZFVQJNN-ZDUSSCGKSA-N
SMILES: NC([C@@H](OC1=CC(OCC2=C3C=C(C4=NC=NC(NCC)=C4)C=C2)=C3C=C1)C)=O
Biological Activity:
XJTU-L453 is a PI3Kα inhibitor with an IC50 value of 0.4 nM. XJTU-L453 can inhibit the proliferation of breast cancer cell lines T47D and MCF7, with IC50 values of 0.2 μM and 0.5 μM, respectively. XJTU-L453 can inhibit the PI3K pathway, induce cell cycle arrest, and trigger cell apoptosis (apoptosis). XJTU-L453 also has antitumor activity in MCF7 xenograft mice[1].
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XJTU-L453 | XJTU-L453 is a PI3Kα inhibitor with an IC50 value of 0.4 nM. XJTU-L453 can inhibit the proliferation of breast cancer cell lines T47D and MCF7, with IC50 values of 0.2 μM and 0.5 μM, respectively. XJTU-L453 can inhibit the PI3K pathway, induce cell cycle arrest, and trigger cell apoptosis (apoptosis). XJTU-L453 also has antitumor activity in MCF7 xenograft mice. |
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References
Keywords
