3031412-84-4

HER2-IN-17 Chemical Structure
3031412-84-4

Chemical Structure

HER2-IN-17

  • CAS No.: 3031412-84-4
  • Formula:C28H24N10O2
  • Molecular Weight:532.56

InChIKey: KUVIPLMYEIFASB-UHFFFAOYSA-N

SMILES: C=CC(N1CC(C1)N2C=C(C=N2)C3=C4C(NC5=CC=C(C(C)=C5)OC6=CC7=NC=NN7C=C6)=NC=NN4C=C3)=O

Biological Activity: HER2-IN-17 (Compound 2) is an inhibitor for HER2, which inhibits the Her YVMA exon 20 insertion mutation (HER2 YVMA) with an IC50 <200 nM. HER2-IN-17 inhibits proliferation of HER2 YVMA mutated BaF3 cells with an IC50 <200 nM and amliorates non-small-cell lung cancer (NSCLC)[1].

Cat. No. Product Name Purity Description Pricing
HY-163418 		HER2-IN-17 HER2-IN-17 (Compound 2) is an inhibitor for HER2, which inhibits the Her YVMA exon 20 insertion mutation (HER2 YVMA) with an IC50 <200 nM. HER2-IN-17 inhibits proliferation of HER2 YVMA mutated BaF3 cells with an IC50 <200 nM and amliorates non-small-cell lung cancer (NSCLC).
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