3031765-17-7
3031765-17-7
Chemical Structure
Patamostat hydrochloride
Synonym(s): E-3123 hydrochloride
- CAS No.: 3031765-17-7
- Formula:C20H21ClN4O4S
- Molecular Weight:448.92
SMILES: O=C(C1=CC=C(NC(N)=N)C=C1)OC2=CC=C(C=C2)SCCN3C(CCC3=O)=O.Cl
Biological Activity: Patamostat hydrochloride is a potent protease inhibitor. Patamostat hydrochloride potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat hydrochloride may possess suppressing effects on pathogenesis and development of acute pancreatitis[1][2].
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Patamostat hydrochloride | Patamostat hydrochloride is a potent protease inhibitor. Patamostat hydrochloride potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat hydrochloride may possess suppressing effects on pathogenesis and development of acute pancreatitis. | |||||||||||||||||||||
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References
- [1]. K Miyamoto, et al. [Effects of E-3123, a New Protease Inhibitor, on Several Protease Activities and on Experimental Acute Pancreatitis]. Nihon Yakurigaku Zasshi. 1988 May;91(5):285-93. [Content Brief]
- [2]. T Hirano, et al. Protective Effect of a Cephalosporin, Shiomarin, Plus a New Potent Protease Inhibitor, E3123, on Rat Taurocholate-Induced Pancreatitis. J Gastroenterol Hepatol. Jan-Feb 1993;8(1):52-9. [Content Brief]
Keywords
