3037993-97-5
Chemical Structure
PARP1/BRD4-IN-2
- CAS No.: 3037993-97-5
- Formula:C25H20N4O4
- Molecular Weight:440.45
IUPAC Name: 5,7-dimethoxy-2-(3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl)quinazolin-4(3H)-one
InChIKey: VNFNYBBLPFNLBF-UHFFFAOYSA-N
SMILES: O=C1C2=CC=CC=C2C(CC3=CC=CC(C4=NC5=CC(OC)=CC(OC)=C5C(N4)=O)=C3)=NN1
Biological Activity: PARP1/BRD4-IN-2 is a potent and selective PARP1 and BRD4 inhibitor with IC50 values of 197 nM and 238 nM, respectively. PARP1/BRD4-IN-2 inhibits DNA damage repair, arrests G0/G1 transition and induces apoptosis. PARP1/BRD4-IN-2 has anti-tumor activity in MDA-MB-468 xenograft mouse model. PARP1/BRD4-IN-2 can be used for researching triple-negative breast cancer (TNBC)[1].
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PARP1/BRD4-IN-2 | PARP1/BRD4-IN-2 is a potent and selective PARP1 and BRD4 inhibitor with IC50 values of 197 nM and 238 nM, respectively. PARP1/BRD4-IN-2 inhibits DNA damage repair, arrests G0/G1 transition and induces apoptosis. PARP1/BRD4-IN-2 has anti-tumor activity in MDA-MB-468 xenograft mouse model. PARP1/BRD4-IN-2 can be used for researching triple-negative breast cancer (TNBC). | |||||||||||||||||||||
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Keywords
