3038810-09-9
Chemical Structure
AChE/BChE-IN-16
- CAS No.: 3038810-09-9
- Formula:C33H34FN5O2
- Molecular Weight:551.65
InChIKey: ZMLLZOVFQZLICZ-UHFFFAOYSA-N
SMILES: O=C(NCCCCCCNC1=C(C=CC(F)=C2)C2=NC3=C1CCCC3)OC4=CC=C(C(N5)=CC6=C5N=CC=C6)C=C4
Biological Activity: AChE/BChE-IN-16 (compound C7) is a potent cholinesterase (ChE) inhibitor with IC50s of 30 nM and 48 nM for human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), respectively. AChE/BChE-IN-16 exhibits a remarkable capacity to safeguard PC12 cells against H2O2-induced apoptosis and effectively suppresses the production of reactive oxygen species (ROS)[1].
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AChE/BChE-IN-16 | AChE/BChE-IN-16 (compound C7) is a potent cholinesterase (ChE) inhibitor with IC50s of 30 nM and 48 nM for human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), respectively. AChE/BChE-IN-16 exhibits a remarkable capacity to safeguard PC12 cells against H2O2-induced apoptosis and effectively suppresses the production of reactive oxygen species (ROS). | |||||||||||||||||||||
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Keywords
