3043670-68-1
3043670-68-1
Chemical Structure
PROTAC K-Ras Degrader-3
- CAS No.: 3043670-68-1
- Formula:C57H67F2N9O6
- Molecular Weight:1012.20
InChIKey: WNKAAEVPMKKCRG-PAKSXQJZSA-N
SMILES: FC1=C(CC)C2=C(C3=C(F)C4=NC(OCC5(CC5)CN6CCC(CN7CC8(CCN(C9=CC=C(C(N([C@@H]%10C(NC(CC%10)=O)=O)C%11)=O)C%11=C9)CC8)C7)(C)CC6)=NC(N%12C[C@@](O)(C)CCC%12)=C4C=N3)C=C(O)C=C2C=C1
Biological Activity: PROTAC K-Ras Degrader-3 (compound 40) is a PROTAC degrader of K-Ras with a DC50 of ≤ 1 nM against SW620 KRAS G12D, and a GI50 of ≤ 10 nM against SW620 3D cell growth. PROTAC K-Ras Degrader-3 can be utilized in cancer research, such as non-small-cell lung cancer (NSCLC)[1].
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PROTAC K-Ras Degrader-3 | 99.75% | PROTAC K-Ras Degrader-3 (compound 40) is a PROTAC degrader of K-Ras with a DC50 of ≤ 1 nM against SW620 KRAS G12D, and a GI50 of ≤ 10 nM against SW620 3D cell growth. PROTAC K-Ras Degrader-3 can be utilized in cancer research, such as non-small-cell lung cancer (NSCLC). | ||||||||||||||||||||
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References
Keywords
