3047672-14-7
3047672-14-7
Chemical Structure
ERG-IN-4
- CAS No.: 3047672-14-7
- Formula:C24H22F3N7O2
- Molecular Weight:497.47
InChIKey: IRMKUPMMVSHMDO-UHFFFAOYSA-N
SMILES: CN(N=C1)C2=C1C(N)=NC3=C2C=C(C(N(N(C(C4CC4)=O)C)CC5=NC=C(C(F)(F)F)C=C5)=O)C=C3
Biological Activity: ERG-IN-4 (Compound 12) is an orally active, selective ERG inhibitor with an IC50 of 5.2 μM for hERG. ERG-IN-4 activates PXR. ERG-IN-4 exhibits anticancer activity against MTAP-deleted non-small cell lung cancer[1].
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ERG-IN-4 | ERG-IN-4 (Compound 12) is an orally active, selective ERG inhibitor with an IC50 of 5.2 μM for hERG. ERG-IN-4 activates PXR. ERG-IN-4 exhibits anticancer activity against MTAP-deleted non-small cell lung cancer. | |||||||||||||||||||||
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References
Keywords
