304911-08-8
Chemical Structure
CGC-11150
- CAS No.: 304911-08-8
- Formula:C40H90N10·10HCl
- Molecular Weight:1075.82
SMILES: CCNCCCCNCCCCNCCCCNCCCCNC/C=C\CNCCCCNCCCCNCCCCNCCCCNCC.Cl.[10]
Biological Activity: CGC-11150 is a decamine-based polyamine analog that acts as a voltage-dependent pore blocker of Kir channels. CGC-11150 produces voltage-dependent pore block similar to that of Spermine (HY-B1777) in recombinant Kir6.2[N160D, L164C, C166S, Δ36] + SUR1 channels, but with faster on and off rates. CGC-11150 inhibits the development of and induces regression of laser-induced choroidal neovascularization (CNV). CGC-11150 is used in studies related to choroidal neovascularization[1][2].
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CGC-11150 | CGC-11150 is a decamine-based polyamine analog that acts as a voltage-dependent pore blocker of Kir channels. CGC-11150 produces voltage-dependent pore block similar to that of Spermine (HY-B1777) in recombinant Kir6.2[N160D, L164C, C166S, Δ36] + SUR1 channels, but with faster on and off rates. CGC-11150 inhibits the development of and induces regression of laser-induced choroidal neovascularization (CNV). CGC-11150 is used in studies related to choroidal neovascularization. | |||||||||||||||||||||
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References
- [1]. Loussouarn G, et al. Molecular basis of inward rectification: structural features of the blocker defined by extended polyamine analogs. Molecular pharmacology. 2005 Aug;68(2):298-304.
- [2]. Lima e Silva R, et al. Suppression and regression of choroidal neovascularization by polyamine analogues. Investigative ophthalmology & visual science. 2005 Sep;46(9):3323-30.
