CGC-11150
CGC-11150 is a decamine-based polyamine analog that acts as a voltage-dependent pore blocker of Kir channels. CGC-11150 produces voltage-dependent pore block similar to that of Spermine (HY-B1777) in recombinant Kir6.2[N160D, L164C, C166S, Δ36] + SUR1 channels, but with faster on and off rates. CGC-11150 inhibits the development of and induces regression of laser-induced choroidal neovascularization (CNV). CGC-11150 is used in studies related to choroidal neovascularization.
For research use only. We do not sell to patients.
- CAS No.: 304911-08-8
- Formula: C40H90N10·10HCl
- Molecular Weight:1075.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
CGC-11150 (1 μM) induces voltage-dependent inward rectification of Kir6.2-rec channels expressed in COSm6 cells, with blocking characteristics similar to spermine but slightly reduced potency and faster on/off rates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
CGC-11150 (20 μg; intravitreal injection; administered on day 0 and day 7 post-injury) reduces the CNV area by approximately 40% in a mouse model of laser-induced choroidal neovascularization[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (female, 4 to 5 weeks old, laser-induced rupture of Bruch’s membrane)[2]
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Dosage:10 mg/kg; 20 mg/kg (i.p.); 20 μg (intravitreous)
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Administration:i.p.; twice a week; 14 days; i.p.; three times a week; 14 days; intravitreous; on days 0 and 7 after injury
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Result:Caused a small reduction in CNV lesion area.
Was not well tolerated (several mice died), but surviving mice showed a small reduction in CNV lesion area comparable to the 10 mg/kg dose.
Resulted in an approximately 40% reduction in CNV lesion area compared to vehicle-treated or untreated eyes.
Caused retinal damage.
Chemical Information
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CAS No. 304911-08-8
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Molecular Weight 1075.82
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Formula C40H90N10·10HCl
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SMILES
CCNCCCCNCCCCNCCCCNCCCCNC/C=C\CNCCCCNCCCCNCCCCNCCCCNCC.Cl.[10]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CGC-11150 Related Classifications
HY-187718 Related Classifications
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