3052113-26-2
Chemical Structure
AHR antagonist 8
- CAS No.: 3052113-26-2
- Formula:C16H14FN3O2S
- Molecular Weight:331.36
InChIKey: TXPJECNXEFHJRI-UHFFFAOYSA-N
SMILES: O=S(C1=CC2=CN=C(NCC3=CC=C(F)C=C3)N=C2C=C1)(C)=O
Biological Activity: AHR antagonist 8 (compound SG-02) is a regulator of utrophin, a homolog of dystrophin, and an AhR antagonist (Kd: 41.68 nM). Studies have shown that 800 nM of AHR antagonist 8 can upregulate utrophin by 2.7 times. AHR antagonist 8 also stimulates increased MyHC expression, suggesting that it has the potential to enhance myogenesis. After ADME evaluation, AHR antagonist 8 also has a certain oral bioavailability[1].
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AHR antagonist 8 | AHR antagonist 8 (compound SG-02) is a regulator of utrophin, a homolog of dystrophin, and an AhR antagonist (Kd: 41.68 nM). Studies have shown that 800 nM of AHR antagonist 8 can upregulate utrophin by 2.7 times. AHR antagonist 8 also stimulates increased MyHC expression, suggesting that it has the potential to enhance myogenesis. After ADME evaluation, AHR antagonist 8 also has a certain oral bioavailability. | |||||||||||||||||||||
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Keywords
