3057216-63-1

TDI-11055 Chemical Structure
3057216-63-1

Chemical Structure

TDI-11055

  • CAS No.: 3057216-63-1
  • Formula:C22H24N6O
  • Molecular Weight:388.47

InChIKey: QRYISIPABXJVOQ-AWEZNQCLSA-N

SMILES: C[C@H]1CCCN1CC2=CC3=C(N2)C=C(N=C3)NC(C4=CC=C5C(C=NN5C)=C4)=O

Biological Activity: TDI-11055 is a selective and orally active eleven-nineteen leukemia (ENL) inhibitor, which displaces ENL from chromatin by blocking its YEATS domain interaction with acylated histones. TDI-11055 inhibits ENL and AF9 YEATS domains with IC50 values of 50 nM and 70 nM, respectively, and no activity against GAS41 or YEATS2. TDI-11055 decreases chromatin occupancy of ENL-associated complexes, impairs transcription elongation, suppresses key oncogenic gene expression programs, and induces differentiation. TDI-11055 can be used for the research of acute myeloid leukemia[1][2].

Cat. No. Product Name Purity Description Pricing
HY-162350 		TDI-11055 98.18% TDI-11055 is a selective and orally active eleven-nineteen leukemia (ENL) inhibitor, which displaces ENL from chromatin by blocking its YEATS domain interaction with acylated histones. TDI-11055 inhibits ENL and AF9 YEATS domains with IC50 values of 50 nM and 70 nM, respectively, and no activity against GAS41 or YEATS2. TDI-11055 decreases chromatin occupancy of ENL-associated complexes, impairs transcription elongation, suppresses key oncogenic gene expression programs, and induces differentiation. TDI-11055 can be used for the research of acute myeloid leukemia.
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