3064814-26-9
Chemical Structure
PDE4B/D-IN-5
- CAS No.: 3064814-26-9
- Formula:C22H21F2N5O2
- Molecular Weight:425.43
InChIKey: PRNAAXLPEFIAPP-UHFFFAOYSA-N
SMILES: FC([H])(CN1N=C(C2=CC=NN2CC)C3=C1C=CC(NC4=CC=C(CC(O)=O)C=C4)=C3)F
Biological Activity: PDE4B/D-IN-5 (Compound P32) is a peripherally restricted, oral active inhibitor of PDE4B and PDE4D with extremely low blood-brain barrier penetration, with IC50 values of 3.4 nM and 2.2 nM, respectively. PDE4B-IN-8 inhibits the production of TNF-α. PDE4B/D-IN-5 significantly reduces the Bax/Bcl2 ratio, and alleviates oxidative stress by decreasing MPO activity and NO levels. PDE4B/D-IN-5 exhibits anti-inflammatory, antioxidant, and anti-apoptotic activities. PDE4B/D-IN-5 can be used for the research of acute lung injury[1].
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PDE4B/D-IN-5 | PDE4B/D-IN-5 (Compound P32) is a peripherally restricted, oral active inhibitor of PDE4B and PDE4D with extremely low blood-brain barrier penetration, with IC50 values of 3.4 nM and 2.2 nM, respectively. PDE4B-IN-8 inhibits the production of TNF-α. PDE4B/D-IN-5 significantly reduces the Bax/Bcl2 ratio, and alleviates oxidative stress by decreasing MPO activity and NO levels. PDE4B/D-IN-5 exhibits anti-inflammatory, antioxidant, and anti-apoptotic activities. PDE4B/D-IN-5 can be used for the research of acute lung injury. | |||||||||||||||||||||
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Keywords
