3082707-76-1
3082707-76-1
Chemical Structure
GV-001
- CAS No.: 3082707-76-1
- Formula:C17H15N3O3
- Molecular Weight:309.32
InChIKey: OTXMKHZDJCFPCE-UHFFFAOYSA-N
SMILES: O=C(NO)C1=CC=C(CC(N2C)=NC3=C(C=CC=C3)C2=O)C=C1
Biological Activity: GV-001 is a selective and orally active HDAC6 inhibitor with an IC50 of 1.18 nM against HDAC6. GV-001 selectively enhances α-tubulin acetylation, reduces sIL-6 and Collagen I levels, suppresses renal cyst growth, and upregulates PC1 expression. GV-001 can be used for the study of autosomal dominant polycystic kidney disease (ADPKD)[1].
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GV-001 | GV-001 is a selective and orally active HDAC6 inhibitor with an IC50 of 1.18 nM against HDAC6. GV-001 selectively enhances α-tubulin acetylation, reduces sIL-6 and Collagen I levels, suppresses renal cyst growth, and upregulates PC1 expression. GV-001 can be used for the study of autosomal dominant polycystic kidney disease (ADPKD). | |||||||||||||||||||||
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References
Keywords
