3087956-87-1
Chemical Structure
DNA gyrase/Topo IV-IN-1
- CAS No.: 3087956-87-1
- Formula:C44H59NO8
- Molecular Weight:729.94
InChIKey: IEOQAZZCYBXYMQ-PLQXJYEYSA-N
SMILES: O=C1C(C)(C)C(C([C@H](C(C)C)C(C(OCCN2CCCC2)=C([C@H](C(C)C)C(C(C(C)(C)C(C3(C)C)=O)=O)=C3O4)C4=C5C(C(C)C)=O)=C5O6)=C6C1(C)C)=O
Biological Activity: DNA gyrase/Topo IV-IN-1 (Compound 27) is an inhibitor of DNA gyrase and topoisomerase IV, exhibiting antibacterial activity. For Escherichia coli and methicillin-resistant Staphylococcus aureus DNA gyrases, DNA gyrase/Topo IV-IN-1 has an IC50 of 11 and 17 nM respectively, and for topoisomerase IV of Escherichia coli and methicillin-resistant Staphylococcus aureus, the IC50 values are 83 and 21 nM respectively. DNA gyrase/Topo IV-IN-1 can be used for research in the field of anti-infection[1].
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DNA gyrase/Topo IV-IN-1 | DNA gyrase/Topo IV-IN-1 (Compound 27) is an inhibitor of DNA gyrase and topoisomerase IV, exhibiting antibacterial activity. For Escherichia coli and methicillin-resistant Staphylococcus aureus DNA gyrases, DNA gyrase/Topo IV-IN-1 has an IC50 of 11 and 17 nM respectively, and for topoisomerase IV of Escherichia coli and methicillin-resistant Staphylococcus aureus, the IC50 values are 83 and 21 nM respectively. DNA gyrase/Topo IV-IN-1 can be used for research in the field of anti-infection. | |||||||||||||||||||||
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Keywords
