3103996-88-6
Chemical Structure
RSV-IN-14
- CAS No.: 3103996-88-6
- Formula:C22H29N5O3S
- Molecular Weight:443.56
InChIKey: YOTGLOZEUSHDOH-UHFFFAOYSA-N
SMILES: O=S1(CCN(C2=NC(NCC3(N)COC3)=C(CC(C)CC4)C4=N2)CC5=C1C=CC=C5)=O
Biological Activity: RSV-IN-14 is an orally active pre-fusion F protein inhibitor of respiratory syncytial virus (RSV), with a Kd of 5.0 μM, and exhibits lung-targeted distribution properties. RSV-IN-14 binds to the central cavity of the trimeric pre-fusion F protein, locks it in the pre-fusion state, and inhibits the conformational changes required for membrane fusion to block viral entry. RSV-IN-14 suppresses respiratory syncytial virus-induced syncytium formation. RSV-IN-14 can be used in studies on respiratory syncytial virus infection[1].
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RSV-IN-14 | RSV-IN-14 is an orally active pre-fusion F protein inhibitor of respiratory syncytial virus (RSV), with a Kd of 5.0 μM, and exhibits lung-targeted distribution properties. RSV-IN-14 binds to the central cavity of the trimeric pre-fusion F protein, locks it in the pre-fusion state, and inhibits the conformational changes required for membrane fusion to block viral entry. RSV-IN-14 suppresses respiratory syncytial virus-induced syncytium formation. RSV-IN-14 can be used in studies on respiratory syncytial virus infection. | |||||||||||||||||||||
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