3107571-66-1
3107571-66-1
Chemical Structure
FXIIa-IN-6
- CAS No.: 3107571-66-1
- Formula:C30H34N8O3
- Molecular Weight:554.64
InChIKey: REVIGMXLJYNCQJ-IBGZPJMESA-N
SMILES: O=C(C1=C2C(OCC3(CO2)CC3)=C(C=C1)N4C[C@H](CC4)N(C(C)C)C)N5N=C(N=C5N)C6=CN=C7C=CC=CC7=N6
Biological Activity: FXIIa-IN-6 is a potent, selective, and irreversible covalent inhibitor of Factor XIIa (FXIIa) with an IC50 of 2 nM. FXIIa-IN-6 exhibits ≥2,500-fold selectivity over related serine proteases. FXIIa-IN-6 exhibits favorable anticoagulant and anti-inflammatory activities and can be used in sepsis research[1].
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FXIIa-IN-6 | FXIIa-IN-6 is a potent, selective, and irreversible covalent inhibitor of Factor XIIa (FXIIa) with an IC50 of 2 nM. FXIIa-IN-6 exhibits ≥2,500-fold selectivity over related serine proteases. FXIIa-IN-6 exhibits favorable anticoagulant and anti-inflammatory activities and can be used in sepsis research. | |||||||||||||||||||||
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References
Keywords
