3109321-90-3
Chemical Structure
TYMJ-01
- CAS No.: 3109321-90-3
- Formula:C27H28N6O4S
- Molecular Weight:532.61
InChIKey: RHFRUFXVQXTPMC-UHFFFAOYSA-N
SMILES: CC1=C(C=C(C=C1)N2N=C(C(N(C2=O)CCCNS(=O)(C3=C4C=CC=C(C4=CC=C3)N(C)C)=O)=O)C#N)C
Biological Activity: TYMJ-01 is a fluorescent probe and eEF2K degrader. TYMJ-01 induces dose-dependent and specific degradation of eEF2K via the ubiquitin-proteasome pathway, with a DC50 of 82 nM. TYMJ-01 inhibits the proliferation, migration and invasion of triple-negative breast cancer cells. TYMJ-01 enables dynamic fluorescent imaging of eEF2K degradation in triple-negative breast cancer cells; it enhances the anti-tumor activity of Paclitaxel (HY-B0015). TYMJ-01 can be used for the research of triple-negative breast cancer[1].
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TYMJ-01 | TYMJ-01 is a fluorescent probe and eEF2K degrader. TYMJ-01 induces dose-dependent and specific degradation of eEF2K via the ubiquitin-proteasome pathway, with a DC50 of 82 nM. TYMJ-01 inhibits the proliferation, migration and invasion of triple-negative breast cancer cells. TYMJ-01 enables dynamic fluorescent imaging of eEF2K degradation in triple-negative breast cancer cells; it enhances the anti-tumor activity of Paclitaxel (HY-B0015). TYMJ-01 can be used for the research of triple-negative breast cancer. | |||||||||||||||||||||
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Keywords
