3113051-34-3
Chemical Structure
STAT3-IN-53
- CAS No.: 3113051-34-3
- Formula:C33H33F3N8O3S
- Molecular Weight:678.73
InChIKey: FLEZXMQSJSANCT-UHFFFAOYSA-N
SMILES: O=C(OCC)C1=NC=CC(C2=NN=C(NC3=C(N4CCN(CC)CC4)C=C5N(C6CC6)C(C7=CC=C(OC(F)(F)F)C=C7)=NC5=C3)S2)=C1
Biological Activity: STAT3-IN-53 (Compound L20) is a STAT3 inhibitor with a Kd value of 6.16 μM. STAT3-IN-53 binds directly to the SH2 domain of STAT3, inhibits phosphorylation at the Y705 site without affecting the total STAT3 protein level, and suppresses the IL-6/JAK/STAT3 pathway. STAT3-IN-53 downregulates the transcription and expression of cyclin-D1 and c-Myc. STAT3-IN-53 induces cell cycle arrest and promotes Apoptosis. STAT3-IN-53 exhibits anticancer activity against colorectal cancer[1].
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STAT3-IN-53 | STAT3-IN-53 (Compound L20) is a STAT3 inhibitor with a Kd value of 6.16 μM. STAT3-IN-53 binds directly to the SH2 domain of STAT3, inhibits phosphorylation at the Y705 site without affecting the total STAT3 protein level, and suppresses the IL-6/JAK/STAT3 pathway. STAT3-IN-53 downregulates the transcription and expression of cyclin-D1 and c-Myc. STAT3-IN-53 induces cell cycle arrest and promotes Apoptosis. STAT3-IN-53 exhibits anticancer activity against colorectal cancer. | |||||||||||||||||||||
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Keywords
