3121511-19-8
Chemical Structure
LHA930
- CAS No.: 3121511-19-8
- Formula:C54H60Cl2N2Si
- Molecular Weight:836.06
InChIKey: TWGGXNQCZAJBEY-ZSNJKBEMSA-N
SMILES: C[Si]1(C2=C(C=C3C(C(CCCN4CCCCl)=C4C=C3)=C2)C(C5=C(C)C=CC=C5C)=C6C1=CC7=C(C=CC8=C7CCCN8CCCCl)C6C/C=C(C)/CC9=CC=CC=C9)C
Biological Activity: LHA930 is a fluorescent probe for in vivo detection of early-stage ferroptosis. By introducing a 4-phenyl-3-methylbut-2-enyl reactive group responsive to lipid hydrogen abstraction, LHA930 exhibits fluorescence turn-on upon the action of oxidative radicals associated with lipid peroxidation, enabling detection of lipid peroxidation during the early stage of ferroptosis. The detection wavelength of LHA930 is Ex/Em = 860/930 nm. LHA930 can be used for near-infrared fluorescence imaging studies of ferroptosis in APAP-induced mouse liver injury models[1].
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LHA930 | LHA930 is a fluorescent probe for in vivo detection of early-stage ferroptosis. By introducing a 4-phenyl-3-methylbut-2-enyl reactive group responsive to lipid hydrogen abstraction, LHA930 exhibits fluorescence turn-on upon the action of oxidative radicals associated with lipid peroxidation, enabling detection of lipid peroxidation during the early stage of ferroptosis. The detection wavelength of LHA930 is Ex/Em = 860/930 nm. LHA930 can be used for near-infrared fluorescence imaging studies of ferroptosis in APAP-induced mouse liver injury models. | |||||||||||||||||||||
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