3124583-65-6
Chemical Structure
ZX079
- CAS No.: 3124583-65-6
- Formula:C47H56F3N7O7
- Molecular Weight:887.99
InChIKey: RQVSFGRAGJLRNJ-UHFFFAOYSA-N
SMILES: O=C(NC(CC1)=O)C1N(C2=O)C(C(C2=C3)=CC=C3NCCCCCCCCCCCC(N(CC4)CCC4C5=NC6=CC=C(C(C=C7C)=CN(C)C7=O)C=C6N5CCOC(F)(F)F)=O)=O
Biological Activity: ZX079 is a dual BRD4 and CBP PROTAC degrader with a BRD4 DC50 value of 0.035 nM and a CBP DC50 value of < 0.02 nM. ZX079 induces dose- and time-dependent degradation of BRD4 and CBP proteins through recruitment of the cereblon E3 ligase. ZX079 induces apoptosis in MV4-11 and MOLM-13 cells, reduces tumor growth in an acute myeloid leukemia xenograft model. ZX079 can be used for the research of acute myeloid leukemia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
ZX079 | ZX079 is a dual BRD4 and CBP PROTAC degrader with a BRD4 DC50 value of 0.035 nM and a CBP DC50 value of < 0.02 nM. ZX079 induces dose- and time-dependent degradation of BRD4 and CBP proteins through recruitment of the cereblon E3 ligase. ZX079 induces apoptosis in MV4-11 and MOLM-13 cells, reduces tumor growth in an acute myeloid leukemia xenograft model. ZX079 can be used for the research of acute myeloid leukemia. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
