33450-08-7
33450-08-7
Chemical Structure
MK 436
Synonym(s): MK-0436
- CAS No.: 33450-08-7
- Formula:C11H14N4O3
- Molecular Weight:250.25
IUPAC Name: 3-(1-methyl-5-nitro-1H-imidazol-2-yl)-3a,4,5,6,7,7a-hexahydrobenzo[d]isoxazole
InChIKey: SPUUHYKZDFCYGW-UHFFFAOYSA-N
SMILES: O=[N+](C1=CN=C(C2=NOC3CCCCC23)N1C)[O-]
Biological Activity: MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America[1][2].
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MK 436 | MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America. | |||||||||||||||||||||
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References
- [1]. VandenHeuvel, et al. Identification of canine urinary metabolites of the antiprotozoal agent 3a, 4, 5, 6, 7, 7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1, 2-benzisoxazole. Journal of pharmaceutical sciences 69.11 (1980): 1288-1292. [Content Brief]
- [2]. Jennings, et al. Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement. Transactions of the Royal Society of Tropical Medicine and Hygiene 77.5 (1983): 693-698. [Content Brief]
Keywords
