350820-12-1
Chemical Structure
2,6-Dimethylnaphthalene-d12
- CAS. Nr.: 350820-12-1
- Formula:C12D12
- Molecular Weight:168.30
IUPAC Name: 3-(1-oxo-3,5,6,7-tetrahydropyrrolo[3,4-f]isoindol-2(1H)-yl)piperidine-2,6-dione
InChIKey: YGYNBBAUIYTWBF-CLWNCLMISA-N
SMILES: [2H]C([2H])([2H])C(C([2H])=C1[2H])=C([2H])C(C([2H])=C2[2H])=C1C([2H])=C2C([2H])([2H])[2H]
Biological Activity: 2,6-Dimethylnaphthalene-d12 is the deuterated-labeled 2,6-Dimethylnaphthalene (HY-W017280). 2,6-Dimethylnaphthalene is a cytochrome P450 1A2 (CYP1A2) inhibitor, with an IC50 of 52 μM and a pIC50 of 4.28 against human targets. 2,6-Dimethylnaphthalene inhibits the 7-ethoxyresorufin O-dealkylation activity catalyzed by CYP1A2[1][2][3].
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2,6-Dimethylnaphthalene-d12 | 98.85% | 2,6-Dimethylnaphthalene-d12 is the deuterated-labeled 2,6-Dimethylnaphthalene (HY-W017280). 2,6-Dimethylnaphthalene is a cytochrome P450 1A2 (CYP1A2) inhibitor, with an IC50 of 52 μM and a pIC50 of 4.28 against human targets. 2,6-Dimethylnaphthalene inhibits the 7-ethoxyresorufin O-dealkylation activity catalyzed by CYP1A2. | ||||||||||||||||||||
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[1]. Korhonen LE, et al. Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15.
[Content Brief] - [2]. Li J, et al. Improved Transalkylation of C₁₀ Aromatics with 2‑Methylnaphthalene for 2,6‑Dimethylnaphthalene Synthesis over Pd‑Modified Zeolites with Different Framework Structures. Industrial & Engineering Chemistry Research. 2024;63(29):12863‑12874.
- [3]. Zhang C, et al. Methylation of 2‑methylnaphthalene with methanol to 2,6‑dimethylnaphthalene over HZSM‑5 modified by NH₄F and SrO. Chinese Chemical Letters. 2007;18(10):1281‑1284.
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