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Cat. No.: HY-W017280

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2,6-Dimethylnaphthalene

Name: 2,6-Dimethylnaphthalene
Brand: MedChemExpress
SKU: HY-W017280
Price: 25.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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2,6-Dimethylnaphthalene is a cytochrome P450 1A2 (CYP1A2) inhibitor, with an IC₅₀ of 52 μM and a pIC₅₀ of 4.28 against human targets. 2,6-Dimethylnaphthalene inhibits the 7-ethoxyresorufin O-dealkylation activity catalyzed by CYP1A2.

For research use only. We do not sell to patients.

Purity : 99.88%
CAS No.: 581-42-0
Formula: C₁₂H₁₂
Molecular Weight:156.22

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

2,6-Dimethylnaphthalene Chemical Structure

CAS No.: 581-42-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]^[2]^[3]

CYP1A2

52 μM (IC₅₀)

CYP1A2

4.28 μM (pIC₅₀)

All Cytochrome P450 Isoforms :

In Vitro

2,6-Dimethylnaphthalene (10 min preincubation; 20 min incubation) inhibits recombinant human CYP1A2-mediated 7-ethoxyresorufin O-dealkylation with an IC₅₀ of 52 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 581-42-0
Appearance Solid
Molecular Weight 156.22
Formula C₁₂H₁₂
Color White to off-white
SMILES

CC1=CC(C=CC(C)=C2)=C2C=C1
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Korhonen LE, et al. Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15.
[Content Brief]

[2]. Li J, et al. Improved Transalkylation of C₁₀ Aromatics with 2‑Methylnaphthalene for 2,6‑Dimethylnaphthalene Synthesis over Pd‑Modified Zeolites with Different Framework Structures. Industrial & Engineering Chemistry Research. 2024;63(29):12863‑12874.

[3]. Zhang C, et al. Methylation of 2‑methylnaphthalene with methanol to 2,6‑dimethylnaphthalene over HZSM‑5 modified by NH₄F and SrO. Chinese Chemical Letters. 2007;18(10):1281‑1284.

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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