581-42-0
581-42-0
Chemical Structure
2,6-Dimethylnaphthalene
- CAS No.: 581-42-0
- Formula:C12H12
- Molecular Weight:156.22
IUPAC Name: 2,6-dimethylnaphthalene
InChIKey: YGYNBBAUIYTWBF-UHFFFAOYSA-N
SMILES: CC1=CC(C=CC(C)=C2)=C2C=C1
Biological Activity: 2,6-Dimethylnaphthalene is a cytochrome P450 1A2 (CYP1A2) inhibitor, with an IC50 of 52 μM and a pIC50 of 4.28 against human targets. 2,6-Dimethylnaphthalene inhibits the 7-ethoxyresorufin O-dealkylation activity catalyzed by CYP1A2[1][2][3].
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2,6-Dimethylnaphthalene | 99.88% | 2,6-Dimethylnaphthalene is a cytochrome P450 1A2 (CYP1A2) inhibitor, with an IC50 of 52 μM and a pIC50 of 4.28 against human targets. 2,6-Dimethylnaphthalene inhibits the 7-ethoxyresorufin O-dealkylation activity catalyzed by CYP1A2. | ||||||||||||||||||||
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References
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[1]. Korhonen LE, et al. Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15.
[Content Brief] - [2]. Li J, et al. Improved Transalkylation of C₁₀ Aromatics with 2‑Methylnaphthalene for 2,6‑Dimethylnaphthalene Synthesis over Pd‑Modified Zeolites with Different Framework Structures. Industrial & Engineering Chemistry Research. 2024;63(29):12863‑12874.
- [3]. Zhang C, et al. Methylation of 2‑methylnaphthalene with methanol to 2,6‑dimethylnaphthalene over HZSM‑5 modified by NH₄F and SrO. Chinese Chemical Letters. 2007;18(10):1281‑1284.
