354815-43-3
Chemical Structure
Androgen receptor antagonist 4
- CAS No.: 354815-43-3
- Formula:C22H18ClN
- Molecular Weight:331.84
IUPAC Name: 4-(4-chlorophenyl)-3a,4,5,11c-tetrahydro-3H-benzo[f]cyclopenta[c]quinoline
InChIKey: UKVXEQUUZSTQOW-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C2NC3=C(C4=CC=CC=C4C=C3)C5C2CC=C5)C=C1
Biological Activity: Androgen receptor antagonist 4 (Compound AT2) is an androgen receptor (AR) antagonist with an IC50 of 0.15 μM. Androgen receptor antagonist 4 efficiently antagonizes AR transcriptional activity, suppresses downstream target gene of AR, and blocks the DHT-induced AR nuclear translocation. Androgen receptor antagonist 4 shows anticancer activities[1].
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Androgen receptor antagonist 4 | Androgen receptor antagonist 4 (Compound AT2) is an androgen receptor (AR) antagonist with an IC50 of 0.15 μM. Androgen receptor antagonist 4 efficiently antagonizes AR transcriptional activity, suppresses downstream target gene of AR, and blocks the DHT-induced AR nuclear translocation. Androgen receptor antagonist 4 shows anticancer activities. | |||||||||||||||||||||
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Keywords
